the biggest problem i see is the place of your site switch button. for a normal webcomic it would be ok to place it on the right/middle of the site but not for animated stuff. because when i want to go to the first panel from the mouse i go over the other panels which show me already what happens there.
place the pageswitch on the top/left of the page
or change the script of (flash?) so that panel 2 dont show the animation before you had a mouseover over the first panel. and that the third dont animated before you had a mouseover the third ect.